Prevalence and risk factors for modified prescriptions in an Irish community pharmacy

Results In total, 866 prescriptions were examined. The overall prevalence of prescription modifications was 17.9% (155/866), with a mean of 31 modifications per week. Prescription only medicines (POM) comprised 147 (94.8%) of the modifications, 128 (87.1%) of which concerned a prescription error requiring a simple clerical clarification before dispensing could occur, with the remaining 19 (12.9%; average of 3.8 per week) potentially having clinical consequences if left unaltered. Half (51%) of all POM modifications occurred through consultation with the patient or their representative. The following factors were associated with increased risk of POM modifications: being a female patient (OR = 1.605, 95% CI 1.104-2.333, p = 0.013) and being prescribed drugs in the following therapeutic areas: musculo-skeletal (OR = 1.906, 95% CI 1.023-3.551, p = 0.042) and genito urinary system and sex hormones (OR = 3.691, 95% CI 2.255-6.042, p< 0.001). Multivariate analysis showed these were significant independent determinants of POM modifications, remaining so after adjustment.